| District | Vacated by | Reason for change | Successor | Date of successor's formal installation |
| Illinois 2 | Vacant | Jesse Jackson Jr. (D) resigned November 21, 2012, near the end of the previous Congress for health reasons, and declined to take office after being re-elected. A special election was held April 9, 2013. | Robin Kelly (D) | April 11, 2013 |
| South Carolina 1 | Vacant | Tim Scott (R) resigned January 2, 2013, near the end of the previous Congress, when appointed to the Senate. A special election was held May 7, 2013. | Mark Sanford (R) | May 15, 2013 |
| Missouri 8 | Jo Ann Emerson (R) | Incumbent resigned January 22, 2013, to become president and CEO of the National Rural Electric Cooperative Association. A special election was held June 4, 2013. | Jason Smith (R) | June 5, 2013 |
| Massachusetts 5 | Ed Markey (D) | Incumbent resigned July 16, 2013, having been elected to the United States Senate in a special election. A special election was held December 10, 2013. | Katherine Clark (D) | December 12, 2013 |
| Alabama 1 | Jo Bonner (R) | Incumbent resigned August 2, 2013, to become a vice chancellor in the University of Alabama System. A special election was held December 17, 2013. | Bradley Byrne (R) | January 7, 2014 |
| Louisiana 5 | Rodney Alexander (R) | Incumbent resigned September 26, 2013, to become the secretary of the Louisiana Department of Veterans Affairs. A special election was held November 16, 2013. | Vance McAllister (R) | November 21, 2013 |
| Florida 13 | Bill Young (R) | Incumbent died October 18, 2013. A special election was held March 11, 2014. | David Jolly (R) | March 13, 2014 |
| North Carolina 12 | Mel Watt (D) | Incumbent resigned January 6, 2014, to become head of the Federal Housing Finance Agency. A special election was held November 4, 2014. | Alma Adams (D) | November 12, 2014 |
| Florida 19 | Trey Radel (R) | Incumbent resigned January 27, 2014 following a conviction for cocaine possession. A special election was held June 24, 2014. | Curt Clawson (R) | June 25, 2014 |
| New Jersey 1 | Rob Andrews (D) | Incumbent resigned February 18, 2014, to take a position at a Philadelphia law firm. A special election was held November 4, 2014. | Donald Norcross (D) | November 12, 2014 |
| Virginia 7 | Eric Cantor (R) | Incumbent resigned August 18, 2014 following his primary defeat. A special election was held November 4, 2014. | Dave Brat (R) | November 12, 2014 |